What is AKK Probiotic Powder?

Basic Features

AKK probiotic, Akkermansia muciniphila (AKK for short), is a probiotic with unique health benefits. AKK bacteria were first isolated from the stool of healthy adults in 2004 by researchers at the Wageningen Microbiology Laboratory in the Netherlands. It is an intestinal symbiotic bacterium belonging to the phylum Verrucomicrobiae. The bacteria are oval in shape, single or in pairs, and rarely in chains. They are Gram-negative and non-motile. They mainly colonize intestinal mucus. layer. It has significant effects in improving intestinal health, regulating metabolism, anti-inflammation and delaying aging.

Health Benefits

1. Improve metabolic diseases: AKK bacteria are negatively correlated with obesity, diabetes, cardiometabolic diseases and low-grade inflammation. Oral administration of Akkermansia muciniphila improves symptoms associated with metabolic disease in mice. The team of Professor GwangPyo Ko from Seoul National University in South Korea found that the administration of Akkella bacteria to obese mice can increase the mice's heat production and cause the mice to lose weight. At the same time, Akkermansia bacteria produce short-chain fatty acids (SCFAs) such as acetate by decomposing mucin, which can suppress appetite and control weight.
2. Regulate intestinal health: AKK bacteria can repair the intestinal mucosa, regulate immunity, and limit the onset of inflammation. In addition, AKK bacteria treatment enhanced intestinal stem cell (ISC) proliferation, accelerated intestinal epithelial regeneration, promoted intestinal epithelial cell (IEC) development, and maintained intestinal homeostasis in a Gpr41/43-dependent manner.
3. Improve neurodegenerative diseases: Studies have found that early high-fat diet can affect the learning and cognitive functions of mice by reducing AKK bacteria in the intestinal flora. This suggests that AKK bacteria may play an important role in neurodegenerative diseases.
4. Anti-inflammatory effect: AKK bacteria have significant anti-inflammatory properties. In germ-free models, liver injury models and obesity models, AKK bacteria can reduce inflammation by regulating the expression of inflammatory markers. In addition, AKK bacteria can prevent non-alcoholic fatty liver disease.
5. Anti-cancer effect: Researchers from Nanjing Medical University found that oral administration of inactivated AKK bacteria or the outer membrane protein Amuc_1100 of AKK bacteria can improve colitis and prevent the occurrence of related intestinal cancer by regulating CD8+ cytotoxic T cells (CTL). .
6. Delay aging: Spanish researchers have confirmed that AKK bacteria can delay aging. After administration of AKK bacteria, the life span of progeria mice was significantly extended.

Supplementation method

There is a certain amount of AKK bacteria in the human body, but it may not be enough. Under the premise of not abusing antibiotics and drinking less alcohol, you can supplement the prebiotics that AKK bacteria like to promote its growth. Studies have found that polyphenols such as anthocyanins (such as those contained in fruits such as cranberries), caffeic acid (such as those contained in lemons), some traditional Chinese medicine ingredients, probiotics, etc. may increase the abundance of AKK bacteria and can be supplemented appropriately.

Application prospects

1. Food additives: AKK bacteria can be used as probiotic additives and added to foods such as yogurt, beverages, and health products to improve the health value of food.
2. Medical raw materials: With the deepening of research on AKK bacteria, its medical application prospects are becoming more and more broad. In the future, AKK bacteria is expected to become a new drug or auxiliary treatment for metabolic diseases such as obesity, diabetes, and liver disease.
3. Cosmetics materials: The anti-inflammatory and anti-aging properties of AKK bacteria also make it have potential application value in the field of cosmetics and daily necessities. For example, it can be added to skin care products to improve the anti-wrinkle, moisturizing and other effects of the product.

Notes

1. Although AKK probiotics have many health benefits, they cannot replace medicine.
2. When choosing AKK probiotics products, you should pay attention to the product's source, ingredients, suitable population and shelf life.
3. Special groups such as pregnant women and children should consult a doctor or professional before use.